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Microplate lids are used to cover plates to protect well contents from leakage, contamination, and evaporation during assay processing, incubation, or storage. Lids are available for a variety of plates, and in a variety of materials, many with specific applications, including storage, fluorescence assays, luminescence assays, microscopy, and cell culture.
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A disulfide bond-containing ionizable cationic lipid has been used in the generation of LNPs for plasmid delivery in vitro and in vivo LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP increase RRSP levels and decrease Ras levels in and reduce the viability of HeLa cancer cells LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart liver spleen lungs and kidneys as well as decrease tumor volume without reducing body weight in an HCT116 colorectal cancer mouse xenograft model
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